End-to-end LFA development for point-of-care testing (POCT) and companion diagnostics (CDx).
Leveraging our K-One surface chemistry and expertise in both SPR chip functionalization and nanoparticle bioconjugation, we support diagnostic companies and biopharma in their LFA development; from optimal antibody pair selection and proof-of-concept development to manufacturing of high-performance gold bioconjugates detection labels.
The state of LFA development today.
AuNPs and colored latex beads are widely used for applications requiring moderate analytical sensitivity. When higher sensitivity is needed, developers increasingly turn to fluorescent latex beads, or to luminescent particles — a high-investment solution that achieves very high sensitivity. However, regardless of the conjugation method employed — passive adsorption or covalent coupling — these approaches present inherent trade-offs that compromise assay performance. Most critically, non-specific binding (NSB), especially prevalent with fluorescent and luminescent particles, increases false positive rates, potentially disqualifying tests from commercialization and patient use.
Beyond passive and covalent coupling: K-One Self-Assembled Monolayer (SAM)
K-One surface chemistry is Kimialys’ proprietary technology platform for controlled antibody immobilization onto gold nanoparticles and chips. This coating enables precise control over surface interactions while preventing non-specific binding.
Kinetics-based antibody selection
Accelerate the process by up to 5x and guarantee optimal selection, ultimately saving months of development.
Highly-sensitive tests
Develop LFA tests with up to 10x better Limit of Detection (LoD) compared to gold standards.
Cost-effective
Reduce antibody consumption by up to 30×, significantly lowering the overall cost of your tests.
Highly-specific tests
Significantly reduce Non-Specific Bindings (NSB) to minimize false results and ensure clear test strips.
Compatible with all sample types
Achieve consistent and reliable results in complex samples (such as blood, plasma, saliva, urine, and milk).
Accelerate Time to Market
Simplify every stage of your assay development — from antibody selection to PoC, optimization, and validation.
You’ll first connect with our sales team (Nicolas, Adrien or Cyril) to discuss your needs and project goals.
You’ll meet our technical team to dive deep into your application and challenges. Based on these discussions, we build a detailed work plan and list all required materials).
Once we agree on scope, timing, material and cost, we move straight to practical implementation.
One week before work begins, we hold a comprehensive kick-off meeting where all details are finalized and final questions are answered. This is the moment to meet the person in charge of the project at Kimialys, who will be your contact throughout the entire project.
From there, you stay connected with our experimentalists at every step, keeping you fully informed on progress.
Fast-paced reliable antibody selection with multiplexed SPRi.
K-One powered gold bioconjugates development.
Membrane striping, conjugate spraying/drying, and card assembly.
Assay runs and preliminary performance assessment in buffer (LoD, dynamic range, etc.).
Duration: 8-12 weeks
Membrane and pads, spraying and running buffer optimization, final design.
Preliminary performance assessment in patient samples (LoD, false pos./neg., variability).
Duration: 4-6 weeks
Production of multiple R&D lots.
Full performance assessment in clinical studies (sensitivity, specificity, etc.)
Transfer to manufacturing.
Supply of small to large volumes of ready-to-use bioconjugates manufactured by Kimialys.
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Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
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