Everything is under control.
K-One surface chemistry allows the covalent immobilization of antibodies on the surface of the gold nanoparticles (AuNPs). This coating gives us full control of antibody orientation, density and homogeneous distribution on the nanoparticle surface, ensuring optimal accessibility for the target. This total control allows us to avoid saturating the surface and reduces the amount of antibodies required for bioconjugation by up to 10–50×.
Our expertise is gold.
The most critical steps in LFA development are antibody selection and bioconjugate optimization, as they play a major role in the final assay sensitivity, specificity, and reproducibility:
- Kinetics-based antibody selection by SPRi (MUST READ PAGE).
- Premium K-One gold bioconjugates.
From concept to market.
Kimialys supports your LFA development from assay design to PoC, clinical testing and manufacturing — either end-to-end or at specific steps.
Product specifications and sourcing (antibodies, antigens, samples, membranes, pads…).
• Fast-paced reliable antibody selection with multiplexed SPRi.
• K-OneR powered gold bioconjugates development.
• Membrane striping, conjugate spraying/drying, and card assembly.
• Assay runs and preliminary performance assessment in buffer (LoD, dynamic range, etc.).
Duration: 6-8 weeks
• Membrane and pads selection, spraying and running buffer optimization, final design.
• Preliminary performance assessment in patient samples (LoD, false pos./neg., variability).
Duration: 2-3 weeks
• Production of multiple R&D lots.
• Full performance assessment in clinical studies (sensitivity, specificity, etc.)
• Transfer to manufacturing.
Supply of small to large volumes of ready-to-use bioconjugates manufactured by Kimialys.
Premium-quality gold bioconjugates
Benefit from our K-One® bioconjugates, ensuring >90% functional ligands while protecting the surface from undesired interactions.
Highly-specific tests
Significantly reduce Non-Specific Bindings (NSB) to minimize false results and ensure clear test strips.
Compatible with all sample types
Achieve consistent and reliable results in complex samples (such as blood, plasma, saliva, urine, and milk).
A novel way to select your antibodies
Accelerate your antibody selection by 5x and save months of development, with our FirstTimeRight method.
Highly-sensitive tests
Develop LFA tests with up to 10x better Limit of Detection (LoD) compared to conventional methods.
A team that genuinely supports you
Work hand-in-hand with our team of engineers, whose cross-disciplinary expertise ensures optimal support throughout all phases of test development.
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Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
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