End-to-end LFA development for POCT and companion diagnostics.
We support diagnostic companies and biopharma by developing proof-of-concepts, selecting the most optimal antibody pairs and manufacturing high-performance gold bioconjugates at scale.
The state of LFA development today.
Passive adsorption is widely used for applications where very low limits of detection (LoD) are not required. When higher sensitivity is needed, developers increasingly turn to fluorescent particles, a high-investment solution that achieves very high sensitivity. However, both approaches carry inherent trade-offs that impact assay performance. In particular, non-specific binding (NSB)—especially with fluorescent particles—increases the risk of false positives or negatives and can ultimately render tests unsuitable for commercialization and patient use.
Beyond passive and fluorescent: the covalent option.
K-One surface chemistry is Kimialys’ technological platform enabling the covalent immobilization of antibodies onto gold nanoparticles. This coating provides full control over surface interactions and shields the surface against NSB.
Kinetics-based antibody selection by SPRi
Guarantee optimal selection and accelerate the process by up to 5×, saving months of development with our FirstTimeRight method: link
Highly-specific tests
Significantly reduce Non-Specific Bindings (NSB) to minimize false results and ensure clear test strips.
Compatible with all sample types
Achieve consistent and reliable results in complex samples (such as blood, plasma, saliva, urine, and milk).
Cost-effective
Reduce antibody consumption by up to 30× and cut 20–40% of the overall assay cost.
Highly-sensitive tests
Develop LFA tests with up to 10x better Limit of Detection (LoD) compared to conventional methods: link
A team that genuinely supports you
Work hand-in-hand with our team of engineers, whose cross-disciplinary expertise ensures optimal support throughout all phases of test development.
Product specifications and sourcing (antibodies, antigens, samples, membranes, pads…).
• Fast-paced reliable antibody selection with multiplexed SPRi.
• K-One powered gold bioconjugates development.
• Membrane striping, conjugate spraying/drying, and card assembly.
• Assay runs and preliminary performance assessment in buffer (LoD, dynamic range, etc.).
Duration: 6-8 weeks
• Membrane and pads selection, spraying and running buffer optimization, final design.
• Preliminary performance assessment in patient samples (LoD, false pos./neg., variability).
Duration: 2-3 weeks
• Production of multiple R&D lots.
• Full performance assessment in clinical studies (sensitivity, specificity, etc.)
• Transfer to manufacturing.
Supply of small to large volumes of ready-to-use bioconjugates manufactured by Kimialys.
Curious about how our Surface Plasmon Resonance expertise can resonate with your current needs?
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Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
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