Your partner of choice for challenging SPR analyses

Say goodbye to your SPR struggles, we are here to change the game!

Kimialys is not a CRO. We are a team of biosensor engineers and chemists with unmatched mastery in SPR assay development, partnering with leading biotech and pharmaceutical companies, as well as CROs and CDMOs.

We provide advanced biophysical analysis services, from molecular interaction screening to in-depth kinetic characterization. Powered by K-One® surface functionalization chemistry, we push the boundaries of SPR, enabling applications that were once impossible and setting new performance standards.

A person holding a Lateral Flow Assay in his hand

5 Reasons to choose Kimialys for your SPR analyses

1

We enable even the most challenging SPR assays by customizing sensors and applying our K-One® chemistry to fit your applications, molecules, and instruments.

2

With K-One®, the chip surface is flawlessly protected, ensuring minimal background noise and delivering consistently clean, reliable sensorgrams, even in complex samples.

3

Ligands remain firmly attached to the chip surface, even after 50+ regeneration cycles, underlining the robustness and reproducibility of the assays conducted with our chips.

4

Our ability to control and adjust ligand density on the chip allows us to work under true affinity conditions and fit data using a 1:1 Langmuir model.

5

Our results are consistent and reliable across a wide range of complex biological matrices, including plasma, serum, and hybridoma/stem cell supernatants.

Kimialys SPR services at a glance

A quick overview of the outcomes you can expect from our SPR services.

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Challenging assays

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Binding interaction screening

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Kinetics analysis

K-One technology pictogram

SNR enhancement

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10x sensitivity

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NSB reduction

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Robust immobilization

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Clean data

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Actionable reports

Applications & use cases

Applications in drug discovery & development:

  • Biologics selection
  • Lead characterization
  • Biosimilarity assessment
  • Antibody screening for CDx
  • Quality control & batch testing
  • Epitope binning

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

Complex molecules we efficiently handle:

  • Antibody

• ADCs
• Nanobodies
• F(ab')₂
• Fc receptors
• mAbs

  • Protein

• C1q
• IDPs
• Membrane receptors
• Coagulation factors
• Lipid-bound proteins

  • Oligonucleotides

• DNA/RNA

FAQ

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How do you optimize antibody pairing for LFA development?
  • Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications

  • Optimal ligand immobilization following Kimialys' proprietary protocol

  • In-house biomolecular interaction analysis with our own SPRi/SPR platforms

  • Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights

Binding interactions screening and epitope binning

We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.

We can immobilize any ligands:

  • Antibodies

  • Nanobodies

  • Small molecules

  • Proteins

  • DNA/RNA

  • Whole cells

  • Peptides

  • Aptamers

  • And more...

Our results are consistent and reliable for any complex biological matrices:

  • Plasma

  • Serum

  • Blood

  • Stem cell supernatant

  • Hybridoma supernatant

  • And more...

Kinetics characterization

Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

How do you optimize antibody for LFA development?
  • Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications

  • Optimal ligand immobilization following Kimialys' proprietary protocol

  • In-house biomolecular interaction analysis with our own SPRi/SPR platforms

  • Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights

Binding interactions screening and epitope binning

We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.

We can immobilize any ligands:

  • Antibodies

  • Nanobodies

  • Small molecules

  • Proteins

  • DNA/RNA

  • Whole cells

  • Peptides

  • Aptamers

  • And more...

Our results are consistent and reliable for any complex biological matrices:

  • Plasma

  • Serum

  • Blood

  • Stem cell supernatant

  • Hybridoma supernatant

  • And more...

Kinetics characterization

Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

How do you optimize antibody pairing for LFA development?
  • Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications

  • Optimal ligand immobilization following Kimialys' proprietary protocol

  • In-house biomolecular interaction analysis with our own SPRi/SPR platforms

  • Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights

Binding interactions screening and epitope binning

We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.

We can immobilize any ligands:

  • Antibodies

  • Nanobodies

  • Small molecules

  • Proteins

  • DNA/RNA

  • Whole cells

  • Peptides

  • Aptamers

  • And more...

Our results are consistent and reliable for any complex biological matrices:

  • Plasma

  • Serum

  • Blood

  • Stem cell supernatant

  • Hybridoma supernatant

  • And more...

Kinetics characterization

Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

What factors impact the accuracy of an LFA test?
  • Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms

  • Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent

Our pre-functionalization technology is compatible with all gold-based sensors.

For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.

We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.

Gold-based sensor types:

  • For common SPR and SPRi platforms: Biacore, Horiba...

  • Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...

  • For chip-based diagnostic applications: electrochemical biosensors, QCM...

K-One® technology licensing

Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.

Still have a question ?

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Contact us