Complete characterisation through precise kinetics, reliable results, and simplified workflows.
We are a team of biosensor engineers and chemists with specialized mastery in SPR assay development. We partner with leading biotech and pharmaceutical companies, as well as CROs and CDMOs, providing advanced biophysical analysis services, from molecular interaction screening to in-depth kinetic characterization.
K-One: redefining surface chemistry.
Powered by K-One surface functionalization chemistry, we push the boundaries of SPR, enabling applications once thought impossible and setting new performance standards.
It's not about generating data, it's about making science of it!
Kimialys' involvement goes beyond our CRO activity, as we help research teams to make real strategic decisions. Our scientists remain closely involved in your projects through presentations, remote meetings, and actionable reports, unlocking new strategic options as results unfold.
Complex systems
We enable even the most challenging SPR assays by customizing sensors and applying our K-One® chemistry to fit your applications, molecules, and instruments.
Non-specific biding reduction
With K-One®, the chip surface is flawlessly protected, ensuring minimal background noise and delivering consistently clean, reliable sensorgrams, even in complex samples.
Robust sensor-chips
Ligands remain firmly attached while maintaining full activity on the surface, enabling repeated injection and regeneration cycles even for challenging interactions — ensuring robust and reproducible assays.
Density control
Our ability to adjust ligand density and control its homogeneous surface distribution allows us to work under affinity conditions by minimizing avidity effects and avoiding recapture. We can also work under avidity conditions when the project requires it.
Complex samples
K-One delivers consistent and reliable results across a wide range of complex biological matrices, including plasma, serum, and hybridoma/stem cell supernatants. Our surface chemistry enables direct ligand immobilization without intermediates, or integrates seamlessly with capture systems like steptavidin, protein A/G, anti-FC and anti-Fab.
Broad compatibility
Our K-One chips work with any gold-based biosensing platform, including Cytiva SPR, Horiba SPRi, Carterra HT-SPR and others. K-One surface chemistry enables direct ligand immobilization without intermediates and can integrate seamlessly with capture systems like streptavidin, protein A/G, anti-FC and anti-Fab.
What you can expect from Kimialys and our K-One SPR services:
SPR services overview
Antibody selection and epitope binning by SPRi
Binding interaction screening
Kinetic characterization:
Benefits
Robust immobilization - Optimal reproducibility
Drastic reduction of non-specific binding in complex samples
Enhanced signal-to-noise ratio- Increased sensitivity (up to 10x)
Collaboration
Clean, reliable data& actionable reports
Strategic scientific partner for long-Term collaboration
Human-centered, video calls and smiles
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique.
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique.
Join our newsletter to stay up to date on features and releases.
By subscribing you agree to with our Privacy Policy and provide consent to receive updates from our company.
