End-to-end LFA development.
Leveraging our proprietary K-One surface chemistry and expertise in both SPR chip functionalization and nanoparticle bioconjugation, we support diagnostic and pharmaceutical companies in lateral flow assay development—including companion diagnostics (CDx)—from optimal antibody pair selection and proof-of-concept development to assay optimization and the manufacturing of high-performance gold bioconjugate detection labels.
The state of LFA development today.
Gold nanoparticles and colored latex beads are widely used in LFAs requiring moderate analytical sensitivity. When higher sensitivity is needed, developers increasingly turn to fluorescent latex beads or luminescent particles. However, both passive adsorption and covalent coupling involve trade-offs that can compromise assay performance. Most critically, non-specific binding (NSB)—especially with fluorescent and luminescent particles—can increase false-positive rates, making the test unreliable for point-of-care testing.
Redefining surface chemistry with K-One.
K-One offers precise control over surface interactions—ligand exposure, density, and distribution—while protecting the surface against non-specific binding. We define K-One as an all-in-one chemistry because it enhances sensitivity without compromising other key assay parameters such as selectivity, specificity, or reproducibility. In practice, this means reaching your target limit of detection (LoD) without background noise, false positives, or batch-to-batch variability that compromise assay performance.
Accelerate time to market
Save time at every stage, from antibody selection to bioconjugation, assay optimization, and robust proof-of-concept development.
Cost-effective bioconjugation
Reduce antibody loading on nanoparticles by up to 30x, significantly lowering assay costs.
Hit your target LoD
Develop LFAs with a limit of detection up to 10x lower than gold standards.
Kinetics-based antibody selection
We identify the right antibody pair within 1 to 2 weeks with Kimialys’ First Time Right platform.
Detection without noise
Significantly reduce non-specific binding (NSB) to minimize false positives and ensure clear test strips with no red streaks.
Reliable in complex samples
Achieve consistent and reliable results in complex samples, including plasma, saliva, urine, and milk.
You’ll first connect with our scientific sales team to discuss your needs and project goals.
You’ll meet our technical team to dive deep into your application and challenges. Based on these discussions, we build a detailed work plan and list all required materials.
Once we agree on scope, timing, materials, and cost we move straight to practical implementation.
One week before work begins, we hold a comprehensive kick-off meeting where all details are finalized and final questions are answered. This is the moment to meet the person in charge of the project at Kimialys, who will be your contact throughout the entire project.
From there, you stay connected with our scientists at every step, keeping you informed on progress via regular video calls, where intermediate results are explained and discussed.
Fast-paced, reliable antibody selection with multiplexed SPRi.
K-One powered gold bioconjugate optimization.
Membrane striping, conjugate spraying/drying, and card assembly.
Assay runs and preliminary performance assessment in buffer (LoD and dynamic range).
Duration: 6-8 weeks
Membrane and pads, spraying and running buffer optimization, final design.
Preliminary performance assessment in biological samples (LoD, false pos./neg., variability).
Duration: ~4 weeks
Production of multiple R&D lots.
Full performance assessment in biological samples (sensitivity, specificity, etc.)
Transfer to industrialization and manufacturing
Supply of small to large volumes of ready-to-use bioconjugates manufactured by Kimialys.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique.
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique.
Join our newsletter to stay up to date on features and releases.
By subscribing you agree to with our Privacy Policy and provide consent to receive updates from our company.
