K‑One, optimized surface chemistry for high‑performance biosensing.
We provide custom pre-functionalized sensor chips designed for your ligands, applications and analytical platforms (SPR, electrochemical, and other gold-based sensors). K-One enhances assay performance and ensures reliable data by increasing the signal-to-noise ratio, enabling complex analyses that standard immobilization strategies cannot support.
Custom doesn’t have to be complicated.
Every chip we deliver is ready-to-use, integrates seamlessly into your workflow, and arrives within 2 to 4 weeks. Each batch comes with an assay protocol designed for your specific project, as we believe custom assay development is key to robust analyses.
Broad compatibility with capture systems.
K-One surface chemistry enables direct ligand immobilization without intermediates but can also integrate with capture systems such as streptavidin, protein A/G, anti-FC and anti-Fab.
In addition to supplying chips, Kimialys also offers in-house SPR analysis services (CRO) performed by our team of expert research engineers in SPR.
For details on how K-One chips can improve your analyses, visit our dedicated page:
K-One, addressing key challenges:
Stability & reproducibility through robust, standardized surface functionalization that maintains consistent dielectric properties.
Extended sensor lifetime with protective surface chemistry that prevents drift and degradation.
Selectivity improvement in complex matrices by minimizing non-specific binding events that cause false capacitive changes.
Enhanced binding kinetics via optimized biorecognition element orientation at the sensing interface.
Practical Impact:
Plug-and-play solution with pre-functionalized chips delivering consistent baseline capacitance and response.
Streamlined protocols reducing surface preparation variability and calibration requirements.
Clinical reliability enabling easier regulatory validation for label-free, real-time monitoring applications.
You’ll first connect with our sales team (Nicolas, Adrien or Cyril) to discuss your needs and project goals.
You’ll meet our technical team to dive deep into your application and challenges. Based on these discussions, we build a detailed work plan and list all required materials. Once we agree on scope, timing, and cost, we move straight to practical implementation
One week before work begins, we hold a comprehensive kick-off meeting where all details are finalized and final questions are answered. This is the moment to meet the person in charge of the project at Kimialys, who will be your contact throughout the entire project. From there, you stay connected with our experimentalists at every step, keeping you fully informed on progress.
We deliver a comprehensive final report with all results and findings. Based on our initial agreement, you receive your optimized K-One biochips with buffers and detailed protocols — no chocolate included!
Curious about how our sensor chips can make sense for your needs?
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Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
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