Your biosensing instruments deserve best-in-class sensor-chips.
Using the right molecules, the most advanced biosensing instrument, and the most sensitive transducer is not enough. Without optimal surface chemistry, you’re not unlocking the full potential of your platform. Sensor functionalization matters, a lot! Don’t let suboptimal chemistry compromise your assays.
Kimialys provides custom pre-functionalized sensor chips, specifically designed for your ligands, applications and analytical platforms (SPR, electrochemical, and other gold-based sensors), enhancing the performance and reliability of your whole system.
The main challenges for Surface Plasmon Resonance (SPR) analyses are threefold:
How do we address these challenges?
Complex systems: our chip functionalization capabilities defy current limits, enabling the immobilization and analysis of complex ligands and analytes (e.g., ADCs, nanobodies, F(ab’)₂, C1q, IDPs, membrane proteins, DNA/RNA, coagulation factors, Fc receptors).
Background noise reduction: we significantly improve the Signal to Noise Ratio (SNR), ensuring reliable and clear-cut results in any complex biological samples (e.g, plasma, serum, hybridoma supernatant, cell extract).
Robust immobilization: K-One allows to keep ligands firmly attached to the chip through multiple analysis cycles, guaranteeing highly reproducible and consistent results.
Broad compatibility: our surface chemistry remains open to various ligand immobilization methods, whether covalently or through streptavidin-biotin, protein A/G, and His-tag systems, among others.
Interested in trying K-One® on your gold chips?
The main challenges for electrochemical analyses include Non-Specific Adsorption (NSA), which blocks electron transfer and increases background noise; suboptimal ligand spacing, which hinders electron flow; electrode fouling and poor surface stability, which affect reproducibility.
How do we address these challenges?
Protecting the electrode from NSA: we prevent non-specific adsorption while maintaining electrochemical activity, even for the most complex biological samples. Unlike traditional anti-fouling coatings (PEG, BSA, other SAMs), K-One® reduces NSA without blocking electron transfer, ensuring sensitivity is not compromised for specificity.
Controlling the surface density: we optimize molecular spacing for efficient charge transfer and redox activity.
Ensure long-term reproducibility: we prevent electrode fouling and maintain surface stability, ensuring reliable performance across multiple runs.
Compatible with your systems: our surface chemistry is compatible with a variety of immobilization approaches, including covalent binding or tag-based systems such as streptavidin-biotin, protein A/G, and His-tag.
Interested in trying K-One® on your gold chips?
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Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications
Optimal ligand immobilization following Kimialys' proprietary protocol
In-house biomolecular interaction analysis with our own SPRi/SPR platforms
Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights
We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.
We can immobilize any ligands:
Antibodies
Nanobodies
Small molecules
Proteins
DNA/RNA
Whole cells
Peptides
Aptamers
And more...
Our results are consistent and reliable for any complex biological matrices:
Plasma
Serum
Blood
Stem cell supernatant
Hybridoma supernatant
And more...
Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.
Kinetics measured:
Affinity (KD)
Binding rate constants (kon, koff)
Avidity
Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms
Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent
For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.
We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.
Gold-based sensor types:
For common SPR and SPRi platforms: Biacore, Horiba...
Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...
For chip-based diagnostic applications: electrochemical biosensors, QCM...
Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.
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