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Kimialys
‍in a nutshell

Kimialys is an innovative industrial company specialized in biosensing, enabling laboratories worldwide to develop and produce tomorrow’s diagnostics and therapeutics. With over 100 projects delivered on complex, real-world applications, we are now moving into scale-up and industrialization programs with our clients.

K-One is Kimialys’ proprietary technology, a surface chemistry that powers all our products and services today. It is a self-assembled monolayer (SAM) optimized for gold nanoparticles, chips, and electrodes unlocking applications once out of reach due to technological limitations and setting new standards for surface treatment in biosensing (detection, extraction, screening, characterization).

By combining K-One with our expertise in ligand functionalization, nanoparticle-based assays, and biosensors, we enable advanced applications in diagnostic development, drug discovery, and bioanalysis. Our approach enhances key assay parameters, such as sensitivity, specificity, selectivity, reproducibility, without ever compromising one for another, as well as cost-effectiveness.

To understand why Kimialys and K-One exist, and how they may be relevant to your work, see the document below:

About K-One & Kimialys

01

Event

Bio-EUROPE SPRING

Join us at Bio-Europe Spring, the world’s leading life sciences partnering event, at the Milano Congressi, from 17–19 March 2025.

Bio-EUROPE SPRING

Let’s schedule a meeting

02

News

Interview: Kimialys x La Chemtech

Read the full article from La Chemtech, featuring an interview with Cyril Gilbert, CEO of Kimialys, on the subject: "Improve the performance and push the boundaries of diagnostic tests and in vitro analyses".

Interview: Kimialys x La Chemtech

All the news

03

Article

Accelerating antibody pair selection for rapid LFIA development through SPRi

In a comparative study to evaluate our SPRi-based antibody selection method for LFIA applications, we contrasted Kimialys' proprietary techniques with the traditional method. Kimialys conducted multiplex SPRi screening and characterization on five chosen antibodies to identify and select the most effective pair.

Accelerating antibody pair selection for rapid LFIA development through SPRi

All the articles

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Laboratory

Paris Biotech Santé Cochin – 4th floor
29 rue du Faubourg Saint Jacques, 75014 Paris

HQ

2 rue Dante, 75005, Paris, France

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FAQ

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How do you optimize antibody pairing for LFA development?

  • Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications

  • Optimal ligand immobilization following Kimialys' proprietary protocol

  • In-house biomolecular interaction analysis with our own SPRi/SPR platforms

  • Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights

Binding interactions screening and epitope binning

We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.

We can immobilize any ligands:

  • Antibodies

  • Nanobodies

  • Small molecules

  • Proteins

  • DNA/RNA

  • Whole cells

  • Peptides

  • Aptamers

  • And more...

Our results are consistent and reliable for any complex biological matrices:

  • Plasma

  • Serum

  • Blood

  • Stem cell supernatant

  • Hybridoma supernatant

  • And more...

Kinetics characterization

Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

How do you optimize antibody for LFA development?

  • Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications

  • Optimal ligand immobilization following Kimialys' proprietary protocol

  • In-house biomolecular interaction analysis with our own SPRi/SPR platforms

  • Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights

Binding interactions screening and epitope binning

We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.

We can immobilize any ligands:

  • Antibodies

  • Nanobodies

  • Small molecules

  • Proteins

  • DNA/RNA

  • Whole cells

  • Peptides

  • Aptamers

  • And more...

Our results are consistent and reliable for any complex biological matrices:

  • Plasma

  • Serum

  • Blood

  • Stem cell supernatant

  • Hybridoma supernatant

  • And more...

Kinetics characterization

Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

How do you optimize antibody pairing for LFA development?

  • Pre-functionalization of SPR sensor chips using K-One® surface chemistry, specifically customized to your applications

  • Optimal ligand immobilization following Kimialys' proprietary protocol

  • In-house biomolecular interaction analysis with our own SPRi/SPR platforms

  • Reliable access to binding and kinetics data, complemented by high-quality reports and presentations, offering actionable insights

Binding interactions screening and epitope binning

We harness both our expertise in SPRi and proprietary K-One® technology on chip to swiftly identify and rank both desired and undesired binding interactions among numerous candidates. This ensures our customers receive consistent and reliable results, accelerating their pursuit of new therapeutics.

We can immobilize any ligands:

  • Antibodies

  • Nanobodies

  • Small molecules

  • Proteins

  • DNA/RNA

  • Whole cells

  • Peptides

  • Aptamers

  • And more...

Our results are consistent and reliable for any complex biological matrices:

  • Plasma

  • Serum

  • Blood

  • Stem cell supernatant

  • Hybridoma supernatant

  • And more...

Kinetics characterization

Reliable measurement of kinetic constants is pivotal for the development of new therapeutics. Leveraging our proprietary K-One® technology, we stand out in the SPR landscape by delivering precise characterization analysis for all biologics and compounds.

Kinetics measured:

  • Affinity (KD)

  • Binding rate constants (kon, koff)

  • Avidity

What factors impact the accuracy of an LFA test?

  • Pre-functionalization of sensor chips using K-One® surface chemistry, specifically customized to your applications and analytical platforms

  • Supply of batches of pre-functionalized sensor chips + ligand immobilization protocol and reagent

Our pre-functionalization technology is compatible with all gold-based sensors.

For companies looking to manage their own analyses, yet eager to leverage our expertise in chip functionalization and our proficiency in tackling complex analytical challenges.

We provide custom pre-functionalized sensor chips, specifically designed for your ligands, analytical platform, and applications, ensuring that your analyses run smoothly and effectively.

Gold-based sensor types:

  • For common SPR and SPRi platforms: Biacore, Horiba...

  • Other SPR-based biosensors: LSPR, Fiber Optic SPR, LR-SPR...

  • For chip-based diagnostic applications: electrochemical biosensors, QCM...

K-One® technology licensing

Our K-One® surface chemistry technology is available for licensing, offering the opportunity to integrate it within your own production environment and standards.

Explore partnership opportunities with Kimialys

Still have a question ?

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